More patients live longer on Modern PD*

*Modern PD is the culmination of multiple recent advancements in clinical practice and innovations in technology that, in combination, are yielding improved survival, increasing patient satisfaction and clinical outcomes that in some cases are outpacing those of HD.

The early survival benefit results in a substantial gain of patient life years in PD cohorts relative to HD ones.¹

Multiple studies have shown PD survival rates are improving and in some cases outpacing those of HD

Screenshot 2021-03-04 at 14.47.46.png — Canadian Organ Replacement Registry showed PD to historically have higher mortality risks compared to HD - however from 2000-4 the mortality risk equalized²

USRDS-ESRD database has shown PD to have consistently better survival than HD since 2007³

Danish Society of Nephrology Registry has shown a consistent trend in improving PD mortality risk from 1990-2010⁴

Korean Society of Nephrology has shown an improvement of mortality risk of PD over HD since 2013⁵

ANZ Dialysis and Transplant Registry showed HD had a 23% improvement in mortality risk from 1998-2012 however PD showed a 29% improvement in mortality from 1998-2012¹

PD has been associated with a significant initial survival advantage

In all models referenced below, Modern PD patients showed a greater survival when compared with HD during the first 2 years.¹ During the periods of 3 to 12 months and 12 to 24 months, the unadjusted mortality rates for HD patients were significantly higher than the mortality rates for PD patients.⁶

Relationship of relative mortality risk PD/HD to dialysis duration. 1990-99 versus 2000-10.

Relationship of relative mortality risk - graph — The graph depicts the relationship of relative mortality risk PD/HD to dialysis durations. It showcases a steady decline in 2000-2010 versus 1990-1999, during the time after ESRD.^4,10

Early survival rate: Modern PD 95%, HD 89%⁷

Preservation of Residual
Renal Function

PD Enables better preservation of residual renal function, which is associated with improved patient survival.

30% higher residual GFR over a 12-month period in PD vs HD patients⁸
Longer time to loss of RRF^7,9

Summary of relative risks of death from the meta - graph

During year 1 patients have between 17-44% lower death rate on PD vs HD.

Meta-analysis of 811,319 patients from 18 countries: those who start dialysis with PD have an early survival benefit vs their counterparts who start with HD.

The graphs shows that mortality rates are significantly higher on HD than on PD through the first two years.

Early survival benefit results in more patient years on PD

PD preserves vascular access and reduces the number and risk of invasive interventions and associated complications.^7,10,11,12 Therefore, more patients stay alive longer on PD, especially during the more productive years of their life.

'Your voice. Their choice. Modern PD' graphic — Your voice. Their choice. Modern PD.

See References

Marshall MR, Polkinghorne KR, Kerr PG, Agar JWM, Hawley CM, McDonald SP. Temporal Changes in Mortality Risk by Dialysis Modality in the Australian and New Zealand Dialysis Population. Am J Kidney Dis. 2015;66(3): 489-498.
Yeates K, Zhu N, Vonesh E, Trpeski L, Blake P, Fenton S. Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada. Nephrol Dial Transplant. 2012;27: 3568–3575.
United States Renal Data System. 2017 USRDS annual data report: Volume 2- ESRD in the united states. National Institute of Diabetes and Digestive and Kidney Diseases. Volume: 2, 2017.
Heaf J, Wehberg S. Relative Survival of Peritoneal Dialysis and Haemodialysis Patients: Effect of Cohort and Mode of Dialysis Initiation. PLOS ONE. 2014;9(3):e90119. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090119. [Accessed 4th March 2022].
Lee SW, Lee NR, Son SK, Kim J, Sul AR, Kim Y, et al. Comparative study of peritoneal dialysis versus hemodialysis on the clinical outcomes in Korea: a population-based approach. Scientific Reports. 2019; 9:5905.
Marshall M. The benefit of early survival on PD versus HD - Why this is (still) very important. Peritoneal Dialysis Int. 2020;40(4): 405-418.
Jansen MAM, Hart AAM, Korevaar JC, Dekker FW, Boeschoten EW, Krediet RT. Predictors of the rate of decline of residual renal function in incident dialysis patients. Kidney int. 2002;62: 1046-1053.
Bargman JM, Thorpe KE, Churchill DN. Relative contribution of residual renal function and peritoneal clearance to the adequacy of dialysis: a reanalysis of the CANUSA study. J Am Soc Nephrol. 2001; 12(10): 2158-2162.
Coentrao L, Santos-Araujo C, Dias C, Neto R, Pestana M. Effects of starting hemodialysis with an arteriovenous fistula or central venous catheter compared with peritoneal dialysis: a retrospective cohort study. BMC Nephrol. 2012;13: 88.
Brown EA, Blake PG, Boudville N, Davies S, Arteaga J, Dong J, et al. International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality good-directed peritoneal dialysis. Peritoneal Dialysis International. 2020;40(3): 244-253.

Therapies

Products

Data & Insights

More patients live longer on Modern PD*

The early survival benefit results in a substantial gain of patient life years in PD cohorts relative to HD ones.¹

Multiple studies have shown PD survival rates are improving and in some cases outpacing those of HD

PD has been associated with a significant initial survival advantage

Relationship of relative mortality risk PD/HD to dialysis duration. 1990-99 versus 2000-10.

Preservation of Residual
Renal Function

PD Enables better preservation of residual renal function, which is associated with improved patient survival.

During year 1 patients have between 17-44% lower death rate on PD vs HD.

Meta-analysis of 811,319 patients from 18 countries: those who start dialysis with PD have an early survival benefit vs their counterparts who start with HD.

The graphs shows that mortality rates are significantly higher on HD than on PD through the first two years.

Early survival benefit results in more patient years on PD

PD preserves vascular access and reduces the number and risk of invasive interventions and associated complications.^7,10,11,12 Therefore, more patients stay alive longer on PD, especially during the more productive years of their life.

Want to know more? Click here to see more clinical data on Modern PD

The early survival benefit results in a substantial gain of patient life years in PD cohorts relative to HD ones.1

Multiple studies have shown PD survival rates are improving and in some cases outpacing those of HD

PD has been associated with a significant initial survival advantage

In all models referenced below, Modern PD patients showed a greater survival when compared with HD during the first 2 years.1 During the periods of 3 to 12 months and 12 to 24 months, the unadjusted mortality rates for HD patients were significantly higher than the mortality rates for PD patients.6

Relationship of relative mortality risk PD/HD to dialysis duration. 1990-99 versus 2000-10.

Preservation of Residual Renal Function

PD Enables better preservation of residual renal function, which is associated with improved patient survival.

During year 1 patients have between 17-44% lower death rate on PD vs HD.

Meta-analysis of 811,319 patients from 18 countries: those who start dialysis with PD have an early survival benefit vs their counterparts who start with HD.

The graphs shows that mortality rates are significantly higher on HD than on PD through the first two years.

Early survival benefit results in more patient years on PD

PD preserves vascular access and reduces the number and risk of invasive interventions and associated complications.7,10,11,12 Therefore, more patients stay alive longer on PD, especially during the more productive years of their life.

Want to know more? Click here to see more clinical data on Modern PD

The early survival benefit results in a substantial gain of patient life years in PD cohorts relative to HD ones.¹

Preservation of Residual
Renal Function

PD preserves vascular access and reduces the number and risk of invasive interventions and associated complications.^7,10,11,12 Therefore, more patients stay alive longer on PD, especially during the more productive years of their life.